Dinner

Meatloaf Casserole: The Ultimate Comfort Food Mashup Recipe

BySimon Carel January 6, 2026January 6, 2026

Introduction

Meatloaf Casserole combines the hearty flavors of classic meatloaf with creamy macaroni and cheese for a comforting and satisfying meal. This easy-to-make dish is perfect for family dinners and will quickly become a favorite.

A close-up of a thick layered baked dish with three visible layers: the bottom layer consists of soft macaroni pasta in a creamy light yellow sauce, the middle layer is a rich, crumbly browned ground meat, and the top layer is a golden, bubbly melted cheese with darker browned spots, showing a slightly crispy texture. The dish is served on a white plate with a sprig of fresh green herb at the bottom left corner, sitting on a white marbled surface. Photo taken with an iphone --ar 4:5 --v 7

Ingredients

1 lb ground beef
2 cups uncooked macaroni
2 cups shredded cheddar cheese
1/2 cup diced onion
1/2 cup breadcrumbs
1 large egg
1/4 cup milk (for meatloaf)
2 tbsp butter (for cheese sauce)
2 cups milk (for cheese sauce)
1 tsp salt
1/2 tsp pepper
1/2 tsp paprika
1/2 tsp dry mustard
2 tbsp flour

Instructions

Step 1: Preheat your oven to 350°F (175°C).
Step 2: In a mixing bowl, combine ground beef, diced onion, breadcrumbs, egg, 1/4 cup milk, 1/2 tsp salt, and 1/4 tsp pepper. Mix well and press the mixture evenly into a greased baking dish.
Step 3: Bake the meatloaf base for 20 minutes.
Step 4: While the meatloaf bakes, cook macaroni according to package directions; drain and set aside.
Step 5: To make the cheese sauce, melt butter in a saucepan over medium heat. Stir in flour and cook for one minute, stirring constantly.
Step 6: Gradually whisk in 2 cups of milk until the sauce thickens. Season with remaining salt, pepper, paprika, and dry mustard.
Step 7: Remove the sauce from heat and stir in 1 1/2 cups of shredded cheddar cheese until melted and smooth.
Step 8: Combine the cooked macaroni with the cheese sauce and pour this mixture evenly over the baked meatloaf layer.
Step 9: Sprinkle the remaining 1/2 cup of shredded cheddar cheese on top.
Step 10: Return the casserole to the oven and bake for an additional 25 minutes, or until bubbly and golden on top.

Tips & Variations

For extra flavor, add minced garlic or fresh herbs like parsley to the meatloaf mixture.
Use a mix of cheeses such as mozzarella and gouda for a richer cheese sauce.
Swap ground beef for ground turkey or chicken for a lighter version.
Try topping with crispy breadcrumbs or fried onions for added texture.

Storage

Store leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, cover with foil and warm in a 350°F (175°C) oven for about 15-20 minutes, or until heated through. You can also microwave individual portions, but the oven method helps maintain texture.

How to Serve

A close-up view of a thick, square slice of baked casserole sitting on a white plate, placed on a white marbled surface. The dish shows three main layers: the bottom layer is curly macaroni pasta coated in a creamy, pale yellow cheese sauce, the middle layer is crumbled cooked ground beef with bits of translucent white onion mixed in, and the top layer is a bright orange, slightly browned melted cheddar cheese crust that is bubbly and shiny. Small green parsley leaves are placed around the plate as garnish, and the melted cheese drips slightly over the edges. Photo taken with an iphone --ar 4:5 --v 7

Serve this delicious recipe with your favorite sides.

FAQs

Can I prepare this casserole ahead of time?

Yes, you can assemble the casserole up to the cheese sauce step and refrigerate it for up to 24 hours before baking. Add extra baking time if baking straight from the fridge.

Can I freeze Meatloaf Casserole?

This casserole can be frozen before baking. Wrap it tightly with foil and freeze for up to 2 months. Thaw overnight in the refrigerator and bake as directed, adding a few extra minutes if needed.